FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
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چکیده
منابع مشابه
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification have identified multiple non-HIF targets for FIH. However, the functional consequences of this outs...
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Factor inhibiting HIF (FIH, also known as HIF1AN) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing ankyrin repeat domains (ARDs) have been characterised as substrates of FIH, although there is little evidence for a functional consequence of hydroxylation on these substrates. This study demonstrates that the transient...
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ژورنال
عنوان ژورنال: PLOS Biology
سال: 2016
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1002347